Accumulation of Kynurenine elevates oxidative stress and alters microRNA Profile in Human Bone Marrow Stromal Cells

Kynurenine, a metabolite of tryptophan breakdown, has been shown to increase with age, and plays a vital role in a number of age-related pathophysiological changes, including bone loss. Accumulation of kynurenine in bone marrow stromal cells (BMSCs) has been associated with a decrease in cell prolif...

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Vydáno v:Exp Gerontol
Hlavní autoři: Dalton, Sherwood, Smith, Kathryn, singh, Kanwar, Kaiser, Helen, Kolhe, Ravindra, Mondal, Ashis K., Khayrullin, Andrew, Isales, Carlos M., Hamrick, Mark W., Hill, William D., Fulzele, Sadanand
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6998036/
https://ncbi.nlm.nih.gov/pubmed/31790802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2019.110800
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