AGE-ASSOCIATED INCREASE IN KYNURENINE INHIBITS AUTOPHAGY AND PROMOTES SENESCENCE IN BONE MARROW STEM CELLS

Aging is characterized by progressive decline of tissue functionality and age-related accumulation of cellular and molecular damage leading to multiple pathological conditions including osteoporosis and increased fracture rates. Bone marrow mesenchymal stem cells (BMSCs) play an essential role in bo...

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Vydáno v:Innov Aging
Hlavní autoři: Kondrikov, Dmitry, Elmansi, Ahmed, Shi, Xing-ming, Fulzele, Sadanand, mcGee-Lawrence, Meghan, Hamrick, Mark, Isales, Carlos, Hill, William D
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Session Lb3620 (Late Breaking Poster)
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6845462/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igz038.3469
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