Kynurenine Promotes RANKL-Induced Osteoclastogenesis In Vitro by Activating the Aryl Hydrocarbon Receptor Pathway

There is increasing evidence of the involvement of the tryptophan metabolite kynurenine (KYN) in disrupting osteogenesis and contributing to aging-related bone loss. Here, we show that KYN has an effect on bone resorption by increasing osteoclastogenesis. We have previously reported that in vivo tre...

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Опубликовано в: :Int J Mol Sci
Главные авторы: Eisa, Nada H., Reddy, Sakamuri V., Elmansi, Ahmed M., Kondrikova, Galina, Kondrikov, Dmitry, Shi, Xing-Ming, Novince, Chad M., Hamrick, Mark W., McGee-Lawrence, Meghan E., Isales, Carlos M., Fulzele, Sadanand, Hill, William D.
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7662708/
https://ncbi.nlm.nih.gov/pubmed/33114603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21217931
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