Computationally Aided Discovery of LysEFm5 Variants with Improved Catalytic Activity and Stability

Bacteriophage-derived lysin proteins are potentially effective antimicrobials that would benefit from engineered improvements to their bioavailability and specific activity. Here, the catalytic domain of LysEFm5, a lysin with activity against vancomycin-resistant Enterococcus faecium (VRE), was subj...

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Bibliografiska uppgifter
I publikationen:Appl Environ Microbiol
Huvudupphovsmän: Baryakova, Tsvetelina H., Ritter, Seth C., Tresnak, Daniel T., Hackel, Benjamin J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2020
Ämnen:
Enzymology and Protein Engineering
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997734/
https://ncbi.nlm.nih.gov/pubmed/31811034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02051-19
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