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A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma
Abnormal expression of the E3 ubiquitin ligase A20 has been found in some malignant cancers, including hepatocellular carcinoma (HCC). Here, we discovered that A20 is an E3 ubiquitin ligase for phosphofructokinase, liver type (PFKL) in HCC A20 interacts with PFKL and promotes its degradation, theref...
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| Udgivet i: | Cell Death Dis |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6997366/ https://ncbi.nlm.nih.gov/pubmed/32015333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2278-6 |
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