A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma

Abnormal expression of the E3 ubiquitin ligase A20 has been found in some malignant cancers, including hepatocellular carcinoma (HCC). Here, we discovered that A20 is an E3 ubiquitin ligase for phosphofructokinase, liver type (PFKL) in HCC A20 interacts with PFKL and promotes its degradation, theref...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Feng, Yilu, Zhang, Ye, Cai, Yi, Liu, Ruijie, Lu, Miaolong, Li, Tangzhiming, Fu, Ying, Guo, Ming, Huang, Huichao, Ou, Yifu, Chen, Yongheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997366/
https://ncbi.nlm.nih.gov/pubmed/32015333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2278-6
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