DNMT3A mutants provide proliferating advantage with augmentation of self-renewal activity in the pathogenesis of AML in KMT2A-PTD-positive leukemic cells

Acute myeloid leukemia (AML) with partial tandem duplication of histone-lysine N-methyltransferase 2A (KMT2A-PTD) is a subtype of AML and is associated with adverse survival, yet the molecular pathogenesis of KMT2A-PTD is not fully understood. DNA methyltransferase 3A (DNMT3A) is mutated in various...

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Bibliographic Details
Published in:Oncogenesis
Main Authors: Bera, Rabindranath, Chiu, Ming-Chun, Huang, Ying-Jung, Huang, Gang, Lee, Yun-Shien, Shih, Lee-Yung
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997180/
https://ncbi.nlm.nih.gov/pubmed/32015320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-0191-6
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