Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease

A promising new therapeutic target for the treatment of Alzheimer's disease (AD) is the circadian system. Although patients with AD are known to have abnormal circadian rhythms and suffer sleep disturbances, the role of the molecular clock in regulating amyloid‐beta (Aβ) pathology is still poor...

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Vydáno v:Aging Cell
Hlavní autoři: Lee, Jiyeon, Kim, Do Eon, Griffin, Percy, Sheehan, Patrick W., Kim, Dong‐Hou, Musiek, Erik S, Yoon, Seung‐Yong
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996949/
https://ncbi.nlm.nih.gov/pubmed/31800167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13078
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