Measurement of Oxidatively Induced DNA Damage in Caenorhabditis elegans with High-Salt DNA Extraction and Isotope-Dilution Mass Spectrometry

Caenorhabditis elegans is used extensively as a medical and toxicological model organism. However, little is known about background levels of oxidatively induced DNA damage in the nematode or how culturing methods affect DNA damage levels. The tough C. elegans cuticle makes it challenging to extract...

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Publié dans:Anal Chem
Auteurs principaux: Scanlan, Leona D., Coskun, Sanem Hosbas, Jaruga, Pawel, Hanna, Shannon K., Sims, Christopher M., Almeida, Jamie L., Catoe, David, Coskun, Erdem, Golan, Rachel, Dizdaroglu, Miral, Nelson, Bryant C.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996937/
https://ncbi.nlm.nih.gov/pubmed/31454479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.9b01503
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