Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

Coupling of endoplasmic reticulum (ER) stress to dimerisation-dependent activation of the UPR transducer IRE1 is incompletely understood. Whilst the luminal co-chaperone ERdj4 promotes a complex between the Hsp70 BiP and IRE1’s stress-sensing luminal domain (IRE1(LD)) that favours the latter’s monom...

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Foilsithe in:eLife
Main Authors: Amin-Wetzel, Niko, Neidhardt, Lisa, Yan, Yahui, Mayer, Matthias P, Ron, David
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2019
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996924/
https://ncbi.nlm.nih.gov/pubmed/31873072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50793
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