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Cellular mechanisms of tumour suppression by the retinoblastoma gene

The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad range of paediatric and adult cancers, and a plethora of cellular functions and partners have been identified for the RB protein. Data from human tumours and studies from mouse models indicate that loss of RB funct...

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Detalles Bibliográficos
Publicado en:Nat Rev Cancer
Main Authors: Burkhart, Deborah L., Sage, Julien
Formato: Artigo
Idioma:Inglês
Publicado: 2008
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996492/
https://ncbi.nlm.nih.gov/pubmed/18650841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2399
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