HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells

HBO1 (MYST2/KAT7) is essential for histone 3 lysine 14 acetylation (H3K14ac) but is dispensable for H4 acetylation and DNA replication in mouse tissues. In contrast, previous studies using small interfering RNA (siRNA) knockdown in human cell lines have suggested that HBO1 is essential for DNA repli...

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Udgivet i:Mol Cell Biol
Main Authors: Kueh, Andrew J., Eccles, Samantha, Tang, Leonie, Garnham, Alexandra L., May, Rose E., Herold, Marco J., Smyth, Gordon K., Voss, Anne K., Thomas, Tim
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996278/
https://ncbi.nlm.nih.gov/pubmed/31767635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00506-19
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