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Histone acetylation by Hbo1 tightens replication licensing

In this issue of Molecular Cell, Miotto and Struhl (2010) suggest that replication licensing, the loading of Mcm2-7 onto DNA, is promoted by Hbo1 acetylating histone H4 at replication origins, providing a molecular view of how chromatin status influences origin usage.

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Bibliografiska uppgifter
Huvudupphovsmän: Chadha, Gaganmeet Singh, Blow, J. Julian
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822430/
https://ncbi.nlm.nih.gov/pubmed/20129050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.12.028
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