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Histone acetylation by Hbo1 tightens replication licensing
In this issue of Molecular Cell, Miotto and Struhl (2010) suggest that replication licensing, the loading of Mcm2-7 onto DNA, is promoted by Hbo1 acetylating histone H4 at replication origins, providing a molecular view of how chromatin status influences origin usage.
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2822430/ https://ncbi.nlm.nih.gov/pubmed/20129050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.12.028 |
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