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HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by geminin
HBO1, an H4-specific histone acetylase, is a co-activator of the DNA replication licensing factor Cdt1. HBO1 acetylase activity is required for licensing, because a HAT-defective mutant of HBO1 bound at origins is unable to load the MCM complex. H4 acetylation at origins is cell-cycle regulated, wit...
Tallennettuna:
| Päätekijät: | , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818871/ https://ncbi.nlm.nih.gov/pubmed/20129055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.12.012 |
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