The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing

Geminin is an important regulator of proliferation and differentiation in metazoans, which predominantly inhibits the DNA replication licensing factor Cdt1, preventing genome over-replication. We show that Geminin preferentially forms stable coiled-coil heterodimers with its homologue, Idas. In cont...

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Detalhes bibliográficos
Main Authors: Caillat, Christophe, Pefani, Dafni-Eleftheria, Gillespie, Peter J., Taraviras, Stavros, Blow, J. Julian, Lygerou, Zoi, Perrakis, Anastassis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814758/
https://ncbi.nlm.nih.gov/pubmed/24064211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.491928
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