The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing

Geminin is an important regulator of proliferation and differentiation in metazoans, which predominantly inhibits the DNA replication licensing factor Cdt1, preventing genome over-replication. We show that Geminin preferentially forms stable coiled-coil heterodimers with its homologue, Idas. In cont...

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Bibliografiska uppgifter
Huvudupphovsmän: Caillat, Christophe, Pefani, Dafni-Eleftheria, Gillespie, Peter J., Taraviras, Stavros, Blow, J. Julian, Lygerou, Zoi, Perrakis, Anastassis
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Protein Structure and Folding
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814758/
https://ncbi.nlm.nih.gov/pubmed/24064211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.491928
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