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A two-stage phase II clinical trial design with nested criteria for early stopping and efficacy
We propose a two-stage design for a single arm clinical trial with an early stopping rule for futility. This design employs different endpoints to assess early stopping and efficacy. The early stopping rule is based on a criteria determined more quickly than that for efficacy. These separate criteri...
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| Publicado en: | Pharm Stat |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6996237/ https://ncbi.nlm.nih.gov/pubmed/31507079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pst.1965 |
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