Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3β/Nrf2 Pathway

Folic acid- (FA-) induced kidney injury is characterized by the tubule damage due to the disturbance of the antioxidant system and subsequent interstitial fibrosis. FG-4592 is an inhibitor of prolyl hydroxylase of hypoxia-inducible factor (HIF), an antioxidant factor. The present study investigated...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Li, Xue, Zou, Yu, Xing, Jia, Fu, Yuan-Yuan, Wang, Kai-Yue, Wan, Peng-Zhi, Zhai, Xiao-Yue
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995323/
https://ncbi.nlm.nih.gov/pubmed/32051732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/6286984
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