Enhance transgene responses through improving cellular uptake and intracellular trafficking by bio-inspired non-viral vectors

BACKGROUND: Gene therapy remains a significant challenge due to lots of barriers limiting the genetic manipulation technologies. As for non-viral delivery vectors, they often suffer insufficient performance due to inadequate cellular uptake and gene degradation in endosome or lysosome. The importanc...

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Dettagli Bibliografici
Pubblicato in:J Nanobiotechnology
Autori principali: Ma, Xi-Xi, Xu, Jing-Liang, Jia, Yi-Yang, Zhang, Ya-Xuan, Wang, Wei, Li, Chen, He, Wei, Zhou, Si-Yuan, Zhang, Bang-Le
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995230/
https://ncbi.nlm.nih.gov/pubmed/32005170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12951-020-0582-z
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