DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

DNA damage is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, relationships between DNA damage accumulation, DNA damage response (DDR), and upper and lower motor neuron vulnerability in human ALS are unclear; furthermore, it is unknown whether epigenetic silencing of...

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Detalles Bibliográficos
Publicado en:Acta Neuropathol Commun
Main Authors: Kim, Byung Woo, Jeong, Ye Eun, Wong, Margaret, Martin, Lee J.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995159/
https://ncbi.nlm.nih.gov/pubmed/32005289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0874-4
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