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Resting state structure of the hyperdepolarization activated two-pore channel 3

Voltage-gated ion channels endow membranes with excitability and the means to propagate action potentials that form the basis of all neuronal signaling. We determined the structure of a voltage-gated sodium channel, two-pore channel 3 (TPC3), which generates ultralong action potentials. TPC3 is dist...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dickinson, Miles Sasha, Myasnikov, Alexander, Eriksen, Jacob, Poweleit, Nicole, Stroud, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995003/
https://ncbi.nlm.nih.gov/pubmed/31924746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915144117
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