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Tuning the ion selectivity of two-pore channels

Organellar two-pore channels (TPCs) contain two copies of a Shaker-like six-transmembrane (6-TM) domain in each subunit and are ubiquitously expressed in plants and animals. Interestingly, plant and animal TPCs share high sequence similarity in the filter region, yet exhibit drastically different io...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Guo, Jiangtao, Zeng, Weizhong, Jiang, Youxing
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293054/
https://ncbi.nlm.nih.gov/pubmed/28096396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616191114
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