RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci

BRCA1 promotes error-free, homologous recombination-mediated repair (HRR) of DNA double-stranded breaks (DSBs). When excessive and uncontrolled, BRCA1 HRR activity promotes illegitimate recombination and genome disorder. We and others have observed that the BRCA1-associated protein RAP80 recruits BR...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Vohhodina, Jekaterina, Toomire, Kimberly J., Petit, Sarah A., Micevic, Goran, Kumari, Geeta, Botchkarev, Vladimir V., Li, Zhe, Livingston, David M., Hu, Yiduo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995001/
https://ncbi.nlm.nih.gov/pubmed/31932421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908003117
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