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Loss of BRCA1-A Complex Function in RAP80 Null Tumor Cells
Receptor Associated Protein 80 (RAP80) is a subunit of the BRCA1-A complex and targets BRCA1 to DNA damage sites in response to DNA double strand breaks. Since mutations of BRCA1 are associated with familial ovarian cancers, we screened 26 ovarian cancer-derived cell lines for RAP80 mutations and fo...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3391255/ https://ncbi.nlm.nih.gov/pubmed/22792303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040406 |
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