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Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration

Copper ions are needed for several hallmarks of cancer. However, the involved pathways, mechanisms, and copper-binding proteins are mostly unknown. We recently found that cytoplasmic Antioxidant 1 copper chaperone (Atox1), which is up-regulated in breast cancer, is localized at the lamellipodia edge...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Blockhuys, Stéphanie, Zhang, Xiaolu, Wittung-Stafshede, Pernilla
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2020
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995000/
https://ncbi.nlm.nih.gov/pubmed/31932435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910722117
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