The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila

Environmental cues such as nutrients alter cellular behaviors by acting on a wide array of molecular sensors inside cells. Of emerging interest is the link observed between effects of dietary sugars on cancer proliferation. Here, we identify the requirements of hexosamine biosynthetic pathway (HBP)...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Wong, Kenneth Kin Lam, Liu, Ta-Wei, Parker, Jessica M., Sinclair, Donald A. R., Chen, Yi-Yun, Khoo, Kay-Hooi, Vocadlo, David J., Verheyen, Esther M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994980/
https://ncbi.nlm.nih.gov/pubmed/31932432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912894117
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