The iron chelator Deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability

The iron chelator Deferasirox (DFX) causes severe toxicity in patients for reasons that were previously unexplained. Here, using the kidney as a clinically relevant in vivo model for toxicity together with a broad range of experimental techniques, including live cell imaging and in vitro biophysical...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Gottwald, Esther M., Schuh, Claus D., Drücker, Patrick, Haenni, Dominik, Pearson, Adam, Ghazi, Susan, Bugarski, Milica, Polesel, Marcello, Duss, Michael, Landau, Ehud M., Kaech, Andres, Ziegler, Urs, Lundby, Anne K. M., Lundby, Carsten, Dittrich, Petra S., Hall, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994599/
https://ncbi.nlm.nih.gov/pubmed/32005861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58386-9
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