Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist

Interleukin-2 (IL-2) is a component of most protocols of adoptive cell transfer (ACT) therapy for cancer, but is limited by short exposure and high toxicities. NKTR-214 is a kinetically-engineered IL-2 receptor βγ (IL-2Rβγ)-biased agonist consisting of IL-2 conjugated to multiple releasable polyethy...

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發表在:Nat Commun
Main Authors: Parisi, Giulia, Saco, Justin D., Salazar, Felix B., Tsoi, Jennifer, Krystofinski, Paige, Puig-Saus, Cristina, Zhang, Ruixue, Zhou, Jing, Cheung-Lau, Gardenia C., Garcia, Alejandro J., Grasso, Catherine S., Tavaré, Richard, Hu-Lieskovan, Siwen, Mackay, Sean, Zalevsky, Jonathan, Bernatchez, Chantale, Diab, Adi, Wu, Anna M., Comin-Anduix, Begoña, Charych, Deborah, Ribas, Antoni
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994533/
https://ncbi.nlm.nih.gov/pubmed/32005809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12901-3
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