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Antigen-Specific In vitro Expansion of Factor VIII-Specific Regulatory T Cells Induces Tolerance in Hemophilia A Mice
BACKGROUND: Following protein replacement therapy, one-third of severe hemophilia A patients develop antibodies to factor VIII (FVIII), which also hinders the efficacy of gene therapy. Regulatory T cells (Tregs) have a naturally suppressive function to potentially reduce the immune response to FVIII...
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| Vydáno v: | J Thromb Haemost |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6994379/ https://ncbi.nlm.nih.gov/pubmed/31609041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14659 |
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