In Vivo Expansion of Regulatory T cells With IL-2/IL-2 mAb Complexes Prevents Anti-factor VIII Immune Responses in Hemophilia A Mice Treated With Factor VIII Plasmid-mediated Gene Therapy

Generation of transgene-specific immune responses can constitute a major complication following gene therapy treatment. An in vivo approach to inducing selective expansion of Regulatory T (Treg) cells by injecting interleukin-2 (IL-2) mixed with a specific IL-2 monoclonal antibody (JES6-1) was adopt...

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Detalhes bibliográficos
Main Authors: Liu, Chao-Lien, Ye, Peiqing, Yen, Benjamin C, Miao, Carol H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149174/
https://ncbi.nlm.nih.gov/pubmed/21468007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.61
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