Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069

BACKGROUND: Crystal violet (CV) was used for several years in blood banks to eliminate the parasite Trypanosoma cruzi in endemic areas in order to prevent transfusion-transmitted Chagas disease. One mechanism of action described for CV involves inhibition of proline uptake. In T. cruzi, proline is e...

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Bibliografiska uppgifter
I publikationen:PLoS Negl Trop Dis
Huvudupphovsmän: Sayé, Melisa, Gauna, Lucrecia, Valera-Vera, Edward, Reigada, Chantal, Miranda, Mariana R., Pereira, Claudio A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994103/
https://ncbi.nlm.nih.gov/pubmed/31961864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0007481
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