Altered microtubule structure, hemichannel localization and beating activity in cardiomyocytes expressing pathologic nuclear lamin A/C

Given the clinical effect of laminopathies, understanding lamin mechanical properties will benefit the treatment of heart failure. Here we report a mechano-dynamic study of LMNA mutations in neonatal rat ventricular myocytes (NRVM) using single cell spectroscopy with Atomic Force Microscopy (AFM) an...

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Publicado en:Heliyon
Autores principales: Borin, Daniele, Peña, Brisa, Chen, Suet Nee, Long, Carlin S., Taylor, Matthew R.G., Mestroni, Luisa, Sbaizero, Orfeo
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6992992/
https://ncbi.nlm.nih.gov/pubmed/32021920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2020.e03175
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