Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1

Mitophagy plays an important role in the maintenance of mitochondrial homeostasis. PTEN-induced kinase (PINK1), a key regulator of mitophagy, is degraded constitutively under steady-state conditions. During mitophagy, it becomes stabilized in the outer mitochondrial membrane, particularly under mito...

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Vydáno v:Sci Rep
Hlavní autoři: Igarashi, Ryoko, Yamashita, Shun-ichi, Yamashita, Tomohiro, Inoue, Keiichi, Fukuda, Tomoyuki, Fukuchi, Takeo, Kanki, Tomotake
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6992789/
https://ncbi.nlm.nih.gov/pubmed/32001742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58315-w
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