Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis

The bivalent domain (BD) at promoter region is an unique epigenetic feature poised for activation or repression during cell differentiation in embryonic stem cell. However, the function of BDs in already differentiated cells remains exclusive. By profiling the epigenetic landscape of endothelial cel...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Chen, Jiahuan, Liang, Xiaodong, Zhang, Shasha, Wang, Shiyan, Garcia, Sara P., Yan, Pengyi, Yu, Huijing, Li, Zixuan, Liu, Li, Zhang, Fang, Wei, Weiting, Le, Huangying, Zhang, Yan, Yuan, Guo-cheng, Chen, Sun, Chen, Yingwei, Sun, Kun, Pu, William T., Zhang, Bing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6992747/
https://ncbi.nlm.nih.gov/pubmed/32001672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2228-3
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