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Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming
Rewiring cellular sensors to trigger non-natural responses is fundamental for therapeutic cell engineering. Current designs rely on engineered receptors that are limited to single inputs, and often suffer from high leakiness and low fold induction. Here, we present Generalized Engineered Activation...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6992713/ https://ncbi.nlm.nih.gov/pubmed/32001704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14397-8 |
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