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A compact synthetic pathway rewires cancer signaling to therapeutic effector release

An important goal in synthetic biology is to engineer biochemical pathways to address unsolved biomedical problems. One long-standing problem in molecular medicine is the specific identification and ablation of cancer cells. Here, we describe a method named Rewiring of Aberrant Signaling to Effector...

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發表在:Science
Main Authors: Chung, Hokyung K., Zou, Xinzhi, Bajar, Bryce T., Brand, Veronica R., Huo, Yunwen, Alcudia, Javier F., Ferrell, James E., Lin, Michael Z.
格式: Artigo
語言:Inglês
出版: 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053279/
https://ncbi.nlm.nih.gov/pubmed/31048459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat6982
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