Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management

Opioid drugs are the gold standard for the management of pain, but their use is severely limited by dangerous and unpleasant side effects. All clinically available opioid analgesics bind to and activate the mu-opioid receptor (MOR), a heterotrimeric G-protein-coupled receptor, to produce analgesia....

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Pubblicato in:Front Mol Neurosci
Autori principali: Senese, Nicolas B., Kandasamy, Ram, Kochan, Kelsey E., Traynor, John R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6992652/
https://ncbi.nlm.nih.gov/pubmed/32038168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00005
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