Poly adenosine diphosphate ribose polymerase inhibitors (PARPi) induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts and PDX models

BACKGROUND: Poly adenosine diphosphate ribose polymerase inhibitors (PARPi) exhibit promising activity against ovarian cancers, but efficacy can be limited by acquired drug resistance. Here, we explore the role of autophagy in regulating sensitivity of ovarian cancer cells to PARPi. METHODS: Inducti...

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Vydáno v:Cancer
Hlavní autoři: Santiago-O’Farrill, Janice M., Weroha, S. John, Hou, Xiaonan, Oberg, Ann L., Heinzen, Ethan P., Maurer, Matthew J., Pang, Lan, Rask, Philip, Amaravadi, Ravi K., Becker, Sarah E., Romero, Ignacio, Rubió, M. Jesús, Matias-Guiu, X., Santacana, Maria, Llombart-Cussac, Antonio, Poveda, Andrés, Lu, Zhen, Bast, Robert C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6992526/
https://ncbi.nlm.nih.gov/pubmed/31714594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.32600
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