Poly adenosine diphosphate ribose polymerase inhibitors (PARPi) induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts and PDX models

BACKGROUND: Poly adenosine diphosphate ribose polymerase inhibitors (PARPi) exhibit promising activity against ovarian cancers, but efficacy can be limited by acquired drug resistance. Here, we explore the role of autophagy in regulating sensitivity of ovarian cancer cells to PARPi. METHODS: Inducti...

詳細記述

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書誌詳細
出版年:Cancer
主要な著者: Santiago-O’Farrill, Janice M., Weroha, S. John, Hou, Xiaonan, Oberg, Ann L., Heinzen, Ethan P., Maurer, Matthew J., Pang, Lan, Rask, Philip, Amaravadi, Ravi K., Becker, Sarah E., Romero, Ignacio, Rubió, M. Jesús, Matias-Guiu, X., Santacana, Maria, Llombart-Cussac, Antonio, Poveda, Andrés, Lu, Zhen, Bast, Robert C.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6992526/
https://ncbi.nlm.nih.gov/pubmed/31714594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.32600
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