Poly adenosine diphosphate ribose polymerase inhibitors (PARPi) induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts and PDX models

BACKGROUND: Poly adenosine diphosphate ribose polymerase inhibitors (PARPi) exhibit promising activity against ovarian cancers, but efficacy can be limited by acquired drug resistance. Here, we explore the role of autophagy in regulating sensitivity of ovarian cancer cells to PARPi. METHODS: Inducti...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cancer
Autori principali: Santiago-O’Farrill, Janice M., Weroha, S. John, Hou, Xiaonan, Oberg, Ann L., Heinzen, Ethan P., Maurer, Matthew J., Pang, Lan, Rask, Philip, Amaravadi, Ravi K., Becker, Sarah E., Romero, Ignacio, Rubió, M. Jesús, Matias-Guiu, X., Santacana, Maria, Llombart-Cussac, Antonio, Poveda, Andrés, Lu, Zhen, Bast, Robert C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6992526/
https://ncbi.nlm.nih.gov/pubmed/31714594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.32600
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi