Poly adenosine diphosphate ribose polymerase inhibitors (PARPi) induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts and PDX models

BACKGROUND: Poly adenosine diphosphate ribose polymerase inhibitors (PARPi) exhibit promising activity against ovarian cancers, but efficacy can be limited by acquired drug resistance. Here, we explore the role of autophagy in regulating sensitivity of ovarian cancer cells to PARPi. METHODS: Inducti...

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Publicado no:Cancer
Main Authors: Santiago-O’Farrill, Janice M., Weroha, S. John, Hou, Xiaonan, Oberg, Ann L., Heinzen, Ethan P., Maurer, Matthew J., Pang, Lan, Rask, Philip, Amaravadi, Ravi K., Becker, Sarah E., Romero, Ignacio, Rubió, M. Jesús, Matias-Guiu, X., Santacana, Maria, Llombart-Cussac, Antonio, Poveda, Andrés, Lu, Zhen, Bast, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6992526/
https://ncbi.nlm.nih.gov/pubmed/31714594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.32600
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