Metabolic imaging using hyperpolarized (13)C‐pyruvate to assess sensitivity to the B‐Raf inhibitor vemurafenib in melanoma cells and xenografts

Nearly all melanoma patients with a BRAF‐activating mutation will develop resistance after an initial clinical benefit from BRAF inhibition (BRAFi). The aim of this work is to evaluate whether metabolic imaging using hyperpolarized (HP) (13)C pyruvate can serve as a metabolic marker of early respons...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Acciardo, Stefania, Mignion, Lionel, Lacomblez, Estelle, Schoonjans, Céline, Joudiou, Nicolas, Gourgue, Florian, Bouzin, Caroline, Baurain, Jean‐François, Gallez, Bernard, Jordan, Bénédicte F.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6991684/
https://ncbi.nlm.nih.gov/pubmed/31833658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14890
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