Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1

Targeting endothelial cell (EC) metabolism should impair angiogenesis, regardless of how many angiogenic signals are present. The dependency of proliferating ECs on glucose and glutamine for energy and biomass production opens new opportunities for anti-angiogenic therapy in cancer. The aim of the p...

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Bibliografiske detaljer
Udgivet i:J Clin Med
Main Authors: Schoonjans, Céline A., Mathieu, Barbara, Joudiou, Nicolas, Zampieri, Luca X., Brusa, Davide, Sonveaux, Pierre, Feron, Olivier, Gallez, Bernard
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7602423/
https://ncbi.nlm.nih.gov/pubmed/33076309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm9103308
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