Novel Sulfonanilide Inhibitors of SHIP2 Enhance Glucose Uptake into Cultured Myotubes

[Image: see text] A series of substituted sulfonanilide analogs were prepared and evaluated as novel potent inhibitors of SH2 domain-containing inositol polyphosphate 5′-phosphatase 2 (SHIP2). SHIP2 has been shown to be a new attractive target for the treatment of insulin resistance in type 2 diabet...

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Pubblicato in:ACS Omega
Autori principali: Berg, Mika E. A., Naams, Jette-Britt, Hautala, Laura C., Tolvanen, Tuomas A., Ahonen, Jari P., Lehtonen, Sanna, Wähälä, Kristiina
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6990439/
https://ncbi.nlm.nih.gov/pubmed/32010815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b02944
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