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SHIPping out diabetes—Metformin, an old friend among new SHIP2 inhibitors
SHIP2 (Src homology 2 domain‐containing inositol 5′‐phosphatase 2) belongs to the family of 5′‐phosphatases. It regulates the phosphoinositide 3‐kinase (PI3K)‐mediated insulin signalling cascade by dephosphorylating the 5′‐position of PtdIns(3,4,5)P3 to generate PtdIns(3,4)P2, suppressing the activi...
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| Publicado no: | Acta Physiol (Oxf) |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6916339/ https://ncbi.nlm.nih.gov/pubmed/31342643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apha.13349 |
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