Synthesis and Structure–Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH

Tuberculosis (TB) is a major infectious disease associated increasingly with drug resistance. Thus, new anti-tubercular agents with novel mechanisms of action are urgently required for the treatment of drug-resistant TB. In prior work, we identified compound 1 (cyclohexyl(4-(isoquinolin-5-ylsulfonyl...

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Bibliografiset tiedot
Julkaisussa:Eur J Med Chem
Päätekijät: Singh, Vinayak, Pacitto, Angela, Donini, Stefano, Ferraris, Davide M., Boros, Sándor, Illyés, Eszter, Szokol, Bálint, Rizzi, Menico, Blundell, Tom L., Ascher, David B., Pato, Janos, Mizrahi, Valerie
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Editions Scientifiques Elsevier 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6990405/
https://ncbi.nlm.nih.gov/pubmed/31055147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2019.04.027
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