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Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System

Predicting how pharmaceuticals may affect heart rhythm is a crucial step in drug development and requires a deep understanding of a compound’s action on ion channels. In vitro hERG channel current recordings are an important step in evaluating the proarrhythmic potential of small molecules and are n...

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Bibliografski detalji
Izdano u:Biophys J
Glavni autori: Lei, Chon Lok, Clerx, Michael, Gavaghan, David J., Polonchuk, Liudmila, Mirams, Gary R., Wang, Ken
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6990155/
https://ncbi.nlm.nih.gov/pubmed/31447109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.07.029
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