Preclinical safety evaluation of chimeric antigen receptor-modified T cells against CD19 in NSG mice

BACKGROUND: With the increase of chimeric antigen receptor-modified T (CAR-T) cell therapy, serious complications initiated by CAR-T cells have garnered wide attention. We have previously developed a 4-1BB/CD3-ζ-costimulated CAR-T cells against CD19 (CART19) for adult acute lymphoblastic leukemia (A...

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Detalhes bibliográficos
Publicado no:Ann Transl Med
Main Authors: Wen, Hairuo, Qu, Zhe, Yan, Yujing, Pu, Chengfei, Wang, Chao, Jiang, Hua, Hou, Tiantian, Huo, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6990014/
https://ncbi.nlm.nih.gov/pubmed/32042751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2019.12.03
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