Unbalance Between Sarcoplasmic Reticulum Ca(2 +) Uptake and Release: A First Step Toward Ca(2 +) Triggered Arrhythmias and Cardiac Damage

The present review focusses on the regulation and interplay of cardiac SR Ca(2+) handling proteins involved in SR Ca(2+) uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or different partners’ proteins. These contro...

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Bibliographic Details
Published in:Front Physiol
Main Authors: Federico, Marilén, Valverde, Carlos A., Mattiazzi, Alicia, Palomeque, Julieta
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989610/
https://ncbi.nlm.nih.gov/pubmed/32038301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01630
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