Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity

The ability of the aryl hydrocarbon receptor (AHR) to alter hepatic expression of cholesterol synthesis genes in a DRE-independent manner in mice and humans has been reported. We have examined the influence of functionally distinct classes of AHR ligands on the levels of Niemann-Pick C1-like intrace...

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Bibliographic Details
Published in:Lab Invest
Main Authors: Muku, Gulsum E., Kusnadi, Ann, Kuzu, Guray, Tanos, Rachel, Murray, Iain A., Gowda, Krishne, Amin, Shantu, Perdew, Gary H.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6989381/
https://ncbi.nlm.nih.gov/pubmed/31417158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-019-0306-x
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