High Canonical Wnt/β-Catenin Activity Sensitizes Murine Hematopoietic Stem and Progenitor Cells to DNA Damage

Aging is characterized by the accumulation of DNA damage and a decrease in stem cell functionality, yet molecular mechanisms that limit the maintenance of stem cells in response to DNA damage remain to be delineated. Here we show in mouse models that DNA damage leads to a transient over-activation o...

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Dettagli Bibliografici
Pubblicato in:Stem Cell Rev Rep
Autori principali: Wang, Yiting, Cui, Hui, Tao, Si, Zeng, Ting, Wu, Jianying, Tao, Zhendong, Zhang, Liu, Zou, Bing, Chen, Zhiyang, Garside, George B., Tang, Duozhuang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6987068/
https://ncbi.nlm.nih.gov/pubmed/31797147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12015-019-09930-2
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