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High Canonical Wnt/β-Catenin Activity Sensitizes Murine Hematopoietic Stem and Progenitor Cells to DNA Damage

Aging is characterized by the accumulation of DNA damage and a decrease in stem cell functionality, yet molecular mechanisms that limit the maintenance of stem cells in response to DNA damage remain to be delineated. Here we show in mouse models that DNA damage leads to a transient over-activation o...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Stem Cell Rev Rep
Main Authors: Wang, Yiting, Cui, Hui, Tao, Si, Zeng, Ting, Wu, Jianying, Tao, Zhendong, Zhang, Liu, Zou, Bing, Chen, Zhiyang, Garside, George B., Tang, Duozhuang
פורמט: Artigo
שפה:Inglês
יצא לאור: Springer US 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6987068/
https://ncbi.nlm.nih.gov/pubmed/31797147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12015-019-09930-2
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